gearheaded: You want to run the smallest gearing normally to get the ratio you want. Too often people put too much emphasis on the ratio and have no clue what it means or more importantly what it does. We get people all the time asking for x tooth counts because of the "ratio" but then we tell them "well, you're going to lose about 25mph off your top speed and they drop their jaw "that would suck". Just think about it was does more so then the final ratio. down in the front or up in the rear will yield more acceleration at a loss of top speed.
Now, if you go with smaller sprockets you'll drop weight and can achieve the same thing.
However, you can't go too small in the front or the chain will have to turn in too tight of a radious and you'll destroy the chain. A 14T is the smallest you can go in the front before destroying the chain with a 13T, however most, and I, would agree that you should avoid a 14T as it's borderline. In the rear you need the sprocket tall enough to clear the swingarm. Yes, this will lower the weight of the sprockets, but in all reality unless you're racing it won't make a damn bit of difference. You're talking about saving like 1-2 ounces of weight. It's one of those things I wouldn't over think. If the sprocket you need isn't in stock somewhere you can change the gearing so you can get your bike back on the road fast by say going down 3 in the rear and also one in the front and the gearing will be nearly the same thing. If you're racing as a pro then sure, most go with the smallest sprockets to accomplish what they want, but it's nothing you'll notice by any means.
Just think of how you use your bike and what means the most to you before you pick a gearing as that will determine what gearing you should get. As for trying to get the smallest sprockets you can...you can do that, but it's nothing critical by any means. You'll shed a little weight, but it's even more funny to see someone do that then pick a front sprocket without lightening holes drilled into it. They went with smaller sprockets, but in the end have a heavier set up due to the fact that AFAM doesn't drill all their front sprockets, and Driven or Vortex do. Etc. The brand matters just as much as the size of the sprockets when you're talking about a tiny few ounces.